C-Reactive Protein - Understand the Test (2024)

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This article waslast modified on 5 November 2020.

At a Glance

Why Get Tested?

To identify the presence of inflammation, to determine its severity, and to monitor response to treatment.

When your doctor suspects that you might be suffering from an inflammatory disorder (as with certain types of arthritis and autoimmune disorders or inflammatory bowel disease) or to check for the possibility of infection (especially after surgery)

Sample Required?

A blood sample taken from a vein in your arm

Test Preparation Needed?

None

On average it takes 7 working days for the blood test results to come back from the hospital, depending on the exact tests requested. Some specialist test results may take longer, if samples have to be sent to a reference (specialist) laboratory. The X-ray & scan results may take longer. If you are registered to use the online services of your local practice, you may be able to access your results online. Your GP practice will be able to provide specific details.

If the doctor wants to see you about the result(s), you will be offered an appointment. If you are concerned about your test results, you will need to arrange an appointment with your doctor so that all relevant information including age, ethnicity, health history, signs and symptoms, laboratory and other procedures (radiology, endoscopy, etc.), can be considered.

Lab Tests Online-UK is an educational website designed to provide patients and carers with information on laboratory tests used in medical care. We are not a laboratory and are unable to comment on an individual's health and treatment.

Reference ranges are dependent on many factors, including patient age, sex, sample population, and test method, and numeric test results can have different meanings in different laboratories.

For these reasons, you will not find reference ranges for the majority of tests described on this web site. The lab report containing your test results should include the relevant reference range for your test(s). Please consult your doctor or the laboratory that performed the test(s) to obtain the reference range if you do not have the lab report.

For more information on reference ranges, please read Reference Ranges and What They Mean.

What is being tested?

C-reactive protein (CRP) is an acute phase reactant, a protein made by the liver that is released into the blood within a few hours after tissue injury, the start of an infection or other inflammation. Increased concentrations in the blood can be found after a heart attack, in sepsis, and after a surgical procedure. It is often the first evidence of inflammation or an infection in the body, with rising concentrations frequently preceding pain, fever or other clinical indicators. The concentration of CRP in the blood can jump a thousand-fold in response to inflammation and can be valuable in monitoring disease activity.

The CRP blood test is not diagnostic but it provides information to the doctor as to whether inflammation is present. This information can be used by the doctor in conjunction with other factors, such as signs and symptoms, physical examination and other tests to determine if someone has an acute inflammatory condition, or if they are experiencing a flare-up of a chronic inflammatory disease. The doctor may then follow up with further testing and treatment.

How is the sample collected for testing?

A blood sample is obtained by inserting a needle into a vein in your arm.

Is any test preparation needed to ensure the quality of the sample?

No test preparation is needed.

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Common Questions

  • How is it used?

    CRP is useful in assessing patients with:

    • Inflammatory bowel disease (IBD)
    • Some forms of arthritis
    • Autoimmune diseases
    • A suspected serious bacterial infection, such as sepsis
    • Pelvic inflammatory disease (PID)
    • CRP is also used to monitor patients after surgery or other invasive procedures to detect the presence of an infection during the recovery period.

    While measuring CRP in the blood is not specific enough to diagnose a particular disease, it does serve as a general, non-specific marker for infection and inflammationwhich can alert medical professionals that further testing and treatment may be necessary.

  • When is it requested?

    Because the concentration of CRP increases in severe cases of inflammation, the test is requested when acute inflammation is a risk (such as from an infection after surgery) or suspected based on patient symptoms. It is also requested to help evaluate chronic inflammatory conditions, such as rheumatoid arthritis and lupus (SLE) and is often repeated to determine whether treatment has been effective. This is particularly useful for inflammatory conditions since CRP levels drop as inflammation subsides.

  • What does the test result mean?

    A high or increasing amount of CRP in your blood suggests that you have an acute infection or inflammation but it does not help in identifying its location or the condition causing it. In people with chronic inflammatory conditions, high concentrations of CRP suggest a flare-up or that treatment has not been effective.
    If the CRP concentration in your blood drops, it means that you are getting better and inflammation is being reduced.

    When your results fall below 10 mg/L, you no longer have clinically active inflammation.

  • Is there anything else I should know?

    CRP concentrations can be elevated in the later stages of pregnancy, with use of birth control pills or in women taking hormone replacement therapy. Higher levels of CRP have also been observed in the obese.

    Another test to monitor inflammation is called the erythrocyte sedimentation rate (ESR). Both CRP and ESR are elevated in the presence of inflammation, but the concentration of CRP in the bloodstream rises and falls faster than ESR. CRP levels may therefore fall to normal if you have been treated successfully, such as for a flare-up of arthritis, but your ESR may remain abnormal for a while longer.

  • What are chronic inflammatory diseases?

    Chronic inflammatory diseases are diseases that lead to the development of long-lasting or frequently recurring inflammation. They can be caused by a number of different pathological conditions. Examples include rheumatoid arthritis, lupus, and inflammatory bowel disease (e.g. Crohn's disease or ulcerative colitis).

  • What is the difference between regular CRP and hs-CRP tests?

    Both tests measure the same molecule in the blood. The high sensitivity CRP (hs-CRP) test is not widely used but may be requested on seemingly healthy people to help assess their risk for heart disease. The regular CRP test is requested in patients who are at risk of bacterial or viral infections (such as after surgery) or in patients with chronic inflammatory diseases (such as rheumatoid arthritis).

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Related Content

On This Site
Tests:High-sensitivity C-reactive protein (hs-CRP);erythrocyte sedimentation rate (ESR)
Conditions:Arthritis,Autoimmune Disorders,Inflammatory Bowel Disease,Pelvic Inflammatory Disease,Systemic Lupus Erythematosus,Sepsis,Vasculitis,Meningitis and Encephalitis

Elsewhere On The Web
ACB, Analyte Monographs (AMALC): CRPC-Reactive Protein - Understand the Test (1)
Patient
National Rheumatoid Arthritis Society

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C-Reactive Protein - Understand the Test (2024)

FAQs

C-Reactive Protein - Understand the Test? ›

What is the C-reactive protein (CRP) blood test? The C-reactive protein (CRP) test is a blood test that checks for inflammation in your body. CRP is a protein that is made in your liver and released into your bloodstream. Levels of CRP start to increase very soon after any inflammation or infection affects your body.

How do you read C-reactive protein blood test results? ›

C-reactive protein is measured in milligrams per liter (mg/L). Results equal to or greater than 8 mg/L or 10 mg/L are considered high. Range values vary depending on the lab doing the test. A high test result is a sign of inflammation.

What is the interpretation of C-reactive protein test? ›

Interpretation of CRP levels:

Less than 0.3 mg/dL: Normal (level seen in most healthy adults). 0.3 to 1.0 mg/dL: Normal or minor elevation (can be seen in obesity, pregnancy, depression, diabetes, common cold, gingivitis, periodontitis, sedentary lifestyle, cigarette smoking, and genetic polymorphisms).

When should I worry about C-reactive protein? ›

According to the American Heart Association, results of the hs-CRP can be interpreted as follows: You are at low risk of developing cardiovascular disease if your hs-CRP level is lower than 1.0 mg/L. You are at average risk of developing cardiovascular disease if your levels are between 1.0 mg/L and 3.0 mg/L.

What is an alarming CRP? ›

A CRP test result of more than 50 mg/dL is generally considered severe elevation. Results over 50 mg/L are associated with acute bacterial infections about 90% of the time.

What level of CRP indicates arthritis? ›

Normal C-reactive protein (CRP) levels
C-reactive protein level (in milligrams per liter of blood) in adultsWhat it means
10.0–100.0moderately elevated, which signifies infection or an inflammatory condition such as rheumatoid arthritis (RA), Crohn's disease, or lupus
4 more rows

What level of CRP indicates Crohn's disease? ›

Table I
MarkerCrohn's disease (n = 49)P-value
Median (IQR)
CRP [mg/l]1.14 (0.46–2.56)0.000130
IL-6 [pg/ml]2.05 (1.01–3.20)0.025885
IL-17A [pg/ml]2.01 (1.23–3.34)0.639040
18 more rows
Jan 5, 2021

What illnesses does C-reactive protein show? ›

The C-reactive protein (CRP) test is used to find inflammation in your body. Inflammation could be caused by different types of conditions, such as an infection or autoimmune disorders like rheumatoid arthritis or inflammatory bowel disease. This test measures the amount of CRP in your blood.

What is a C-reactive protein level chart? ›

C-Reactive Protein Test Result
CRP LEVELCLASSIFICATION
Less than 0.3 mg/dL (milligrams per deciliter)Normal
0.3 to 1.0 mg/dLNormal or minor elevation
1.0 to 10.0 mg/dLModerate elevation
More than 10.0 mg/dLMarked elevation
1 more row
Feb 19, 2024

What does C-reactive protein mean in inflammation? ›

CRP is a protein that is made in your liver and released into your bloodstream. Levels of CRP start to increase very soon after any inflammation or infection affects your body. The CRP blood test can be used to find out how severe inflammation is, or whether you are responding to treatment.

What to avoid when C-reactive protein is high? ›

Avoid Foods That Cause Inflammation: Processed meals, sugary snacks, and excessive consumption of red meat can all contribute to inflammation. Limiting these foods in your diet can help lower CRP levels.

How do you fix C-reactive protein? ›

Limiting or avoiding inflammatory foods like refined carbohydrates, fried foods, red meat and processed meat can help reduce CRP. Instead, focus on eating more anti-inflammatory foods like leafy greens, nuts, fatty fish and whole grains.

What is the treatment for high CRP? ›

If you're at high risk of cardiovascular disease and your test results show high CRP, your doctor may suggest a statin or other cholesterol-lowering medication. Vitamin C has also been explored as a way to lower CRP levels for people who have an elevated risk of cardiovascular disease.

What is a bad CRP number? ›

Risk assessment guidelines

The American Heart Association and Centers for Disease Control (CDC) have set the following guidelines: Below 1.0 mg/L: Low risk for heart problems. 1.0 to 3.0 mg/L: Average risk for heart problems. Above 3.0 mg/L: High risk for heart problems.

What is a critical level of CRP? ›

CRP levels can vary widely depending on the underlying condition causing inflammation. Generally, a CRP level of less than 10 mg/L is considered normal. CRP levels between 10 and 100 mg/L indicate mild to moderate inflammation, while levels above 100 mg/L indicate severe inflammation.

Is CRP a tumor marker? ›

Elevated CRP levels predict poor outcome and tumor recurrence in patients with thymic epithelial tumors: A pro- and retrospective analysis.

What is the normal reading for CRP test? ›

Interpreting test results

The report might indicate that the level is high, low, or normal. Although “normal” CRP levels vary from lab to lab, it is generally accepted that a value of 0.8-1.0 mg/dL (or 8-10 mg/L) or lower is normal. Most healthy adults have CRP levels lower than 0.3 mg/dL.

What is out of range for C-reactive protein blood test? ›

A high CRP is more than 10mg/L. This shows that there is inflammation somewhere in your body. Other tests might be necessary to find out where or which specific illness or infection is causing the inflammation. If you are being treated for an infection or inflammation, your CRP levels should decrease.

What is considered high C-reactive protein CRP? ›

High levels of CRP may mean you have a serious health condition that causes inflammation. Inflammation is your body's way of protecting your tissues and helping them heal from an injury, infection, or other disease. Inflammation can be acute (sudden) and temporary.

What is a normal range for high sensitivity CRP? ›

Less than 1.0 mg/L (hs-CRP normal range suggesting no underlying health complications) Between 1.0 mg/L to 3.0 mg/L (the moderate concentration suggesting underlying inflammation and CVD complications) Above 3.0 mg/L (excess concentration indicating CAD issues and chronic illness left untreated)

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